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Home Health

Women Seem to Have Better COVID-19 Outcomes Than Men. Here’s a Theory Why

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February 20, 2022
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Getting vaccinated and boosted dramatically will increase the probability of surviving a case of COVID-19, however many danger elements—like being biologically male—are outdoors of individuals’s management. Within the U.S., 20% extra males have died from COVID-19 than ladies, based on information from the U.S. Facilities for Illness Management and Prevention. Scientists theorize that the distinction in danger between the 2 sexes might, partly, come right down to the hormone estrogen, which performs a job within the immune system.

New analysis printed in BMJ Open on Feb. 14 hyperlinks estrogen ranges to ladies’s probability of dying after they contract COVID-19. Within the research, researchers checked out Swedish nationwide well being registry information from greater than 16,000 ladies, ages 50 to 80, who had examined optimistic for COVID-19 between Feb. 4 and Sept. 14 of 2020. Most had gone via menopause, a time throughout which estrogen sometimes drops.
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Researchers had been notably within the ladies within the group who had been taking medicines that have an effect on estrogen ranges: 227 had been on endocrine remedy, a remedy for breast most cancers that lowers estrogen, and about 2,500 had been present process hormone alternative remedy, which will increase estrogen ranges with a view to scale back menopausal signs.

After researchers factored within the ladies’s comorbidities, age, and socio-economic elements, they discovered that girls who had been taking medicines that raised estrogen ranges had been about half as prone to die from COVID-19 as ladies who weren’t taking medicines that have an effect on estrogen. (There was additionally an preliminary hyperlink between taking estrogen-lowering medicines and having an elevated danger of dying from COVID-19, however after factoring within the confounding variables, it was not vital.)

The discovering matches with these from different observational research which have additionally linked excessive estrogen ranges to a decrease danger of changing into significantly ailing from COVID-19, says Dr. Franck Mauvais-Jarvis, director of the Intercourse-Primarily based Medication Laboratory at Tulane College (who was not concerned within the research). Estrogen—and the hormone progesterone, to a lesser extent—is believed to be concerned within the physique’s immune response and will restrict irritation, he says. In COVID-19, irritation can set off a “cytokine storm,” a harmful situation by which the immune system can get overwhelmed.

Learn Extra: To Ease Menopause Signs, Add a Little Melody

Different analysis means that estrogen may have an effect on spike protein receptors, which SARS-CoV-2—the virus that causes COVID-19—makes use of to get into cells, says Dr. Malin Sund, a professor at Umeå College in Sweden and co-author of the brand new research.

Nonetheless, as Sund and her fellow authors level out, randomized scientific trials are essential to find out whether or not the hyperlink is causal, and if artificially growing estrogen can shield sufferers from COVID-19. The brand new research will not be with out drawbacks; as an illustration, the researchers had been unable to examine the ladies’s hormone ranges over time.

Sund emphasizes that folks mustn’t experiment with altering their estrogen ranges; elevating estrogen ranges can have negative effects, comparable to an elevated danger of breast most cancers. Conversely, “ladies who’ve had breast most cancers ought to completely not cease taking their endocrine remedy primarily based on this research as a result of they actually need their remedy for breast most cancers,” says Sund. “The perfect factor they will do is get vaccinated.”

Many ailments have an effect on women and men otherwise, however all through a lot of historical past, scientific analysis has centered on males alone. The U.S. Nationwide Institutes of Well being didn’t make it an official coverage to incorporate ladies in scientific trials till 1989, and it didn’t require grant candidates to steadiness intercourse in analysis on cells and animals till 2014.

Finding out intercourse variations and illness shouldn’t cease with COVID-19, Mauvais-Jarvis says. “There are loads of ailments—not simply COVID-19—which might be characterised by variations between women and men,” he says.

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google.com,pub-8241049497608997,RESELLER,f08c47fec0942fa0 yahoo.com,1832200,DIRECT,e1a5b5b6e3255540 smartadserver.com,4144,DIRECT smartadserver.com,4016,DIRECT smartadserver.com,4012,DIRECT smartadserver.com,4071,DIRECT smartadserver.com,4073,DIRECT smartadserver.com,4074,DIRECT google.com,pub-8933329999391104,RESELLER,f08c47fec0942fa0 google.com,pub-1325340429823502,RESELLER,f08c47fec0942fa0 google.com,pub-6110672335579159,RESELLER,f08c47fec0942fa0 adpushup.com,cfcb90bc3d34a71413ca5d041db539a8,DIRECT,b0b8ff8485794fdd pubmatic.com,160925,RESELLER,5d62403b186f2ace rubiconproject.com,15636,RESELLER,0bfd66d529a55807 otm-r.com,23,RESELLER taboola.com,1196805,DIRECT,c228e6794e811952 spotx.tv,71451,RESELLER spotxchange.com,71451,RESELLER advertising.com,8603,RESELLER pubmatic.com,156307,RESELLER,5d62403b186f2ace appnexus.com,3364,RESELLER Indexexchange.com,183756,RESELLER contextweb.com,560382,RESELLER openx.com,539154393,RESELLER tremorhub.com,z87wm,RESELLER,1a4e959a1b50034a 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spotxchange.com,173177,DIRECT spotxchange.com,173175,DIRECT yahoo.com,57857,RESELLER,e1a5b5b6e3255540 smartadserver.com,2161,DIRECT pubmatic.com,156439,RESELLER,5d62403b186f2ace pubmatic.com,154037,RESELLER,5d62403b186f2ace rhythmone.com,2564526802,RESELLER,a670c89d4a324e47 adyoulike.com,b4bf4fdd9b0b915f746f6747ff432bde,RESELLER smartadserver.com,3668,DIRECT rubiconproject.com,18194,DIRECT,0bfd66d529a55807 spotx.tv,202009,DIRECT,7842df1d2fe2db34 spotxchange.com,202009,RESELLER,7842df1d2fe2db34 yieldlab.net,6378054,DIRECT freewheel.tv,1076049,DIRECT freewheel.tv,1076065,RESELLER appnexus.com,8833,DIRECT,f5ab79cb980f11d1 appnexus.com,8833,RESELLER,f5ab79cb980f11d1 freewheel.tv,228,RESELLER smartstream.tv,6459,RESELLER appnexus.com,3368,RESELLER yieldlab.net,2172218,RESELLER google.com,pub-9829476400767085,DIRECT,f08c47fec0942fa0 freewheel.tv,1131585,RESELLER piximedia.com,21168,DIRECT adtech.com,4803,RESELLER freewheel.tv,282482,RESELLER freewheel.tv,283026,RESELLER pubmatic.com,156492,RESELLER,5d62403b186f2ace smartadserver.com,3347,DIRECT pubmatic.com,156030,RESELLER,5d62403b186f2ace rubiconproject.com,13132,RESELLER,0bfd66d529a55807 groundtruth.com,107,RESELLER,81cbf0a75a5e0e9a appnexus.com,2579,DIRECT appnexus.com,884,DIRECT improvedigital.com,1220,DIRECT google.com,pub-1313834454494130,RESELLER,f08c47fec0942fa0 google.com,pub-8536066741654249,RESELLER,f08c47fec0942fa0 triplelift.com,4338,DIRECT,6c33edb13117fd86 appnexus.com,1314,RESELLER adform.com,2623,DIRECT,9f5210a2f0999e32 nobid.io,21968366300,DIRECT google.com,pub-1051504991213440,DIRECT,f08c47fec0942fa0 google.com,pub-1835489473992347,DIRECT,f08c47fec0942fa0 google.com,pub-1789253751882305,DIRECT,f08c47fec0942fa0 google.com,pub-1950215063958302,DIRECT,f08c47fec0942fa0 appnexus.com,11429,DIRECT gumgum.com,13926,DIRECT,ffdef49475d318a9 33across.com,0010b00002Mq2FYAAZ,DIRECT,bbea06d9c4d2853c sovrn.com,273657,DIRECT,fafdf38b16bf6b2b lijit.com,273657,DIRECT,fafdf38b16bf6b2b lijit.com,273657-eb,DIRECT,fafdf38b16bf6b2b revcontent.com,124709,DIRECT appnexus.com,7666,RESELLER,f5ab79cb980f11d1 rubiconproject.com,156042,RESELLER,0bfd66d529a55807 my6sense.com,9732,RESELLER criteo.com,7822,RESELLER pubmatic.com,156423,RESELLER,5d62403b186f2ace appnexus.com,1001,RESELLER,f5ab79cb980f11d1 appnexus.com,3135,RESELLER,f5ab79cb980f11d1 openx.com,537120563,RESELLER,6a698e2ec38604c6 openx.com,539392223,RESELLER,6a698e2ec38604c6 rhythmone.com,2439829435,RESELLER,a670c89d4a324e47 emxdgt.com,326,RESELLER,1e1d41537f7cad7f gumgum.com,13318,RESELLER,ffdef49475d318a9 google.com,pub-9557089510405422,RESELLER,f08c47fec0942fa0 adtech.com,9993,RESELLER adtech.com,12094,RESELLER advangelists.com,8d3bba7425e7c98c50f52ca1b52d3735,RESELLER,60d26397ec060f98 rubiconproject.com,13702,DIRECT pubmatic.com,157898,DIRECT,5d62403b186f2ace adtech.com,10109,DIRECT aolcloud.net,10109,DIRECT openx.com,540650310,DIRECT,6a698e2ec38604c6 sonobi.com,bc2afab5f7,DIRECT,d1a215d9eb5aee9e appnexus.com,9538,DIRECT triplelift.com,9789,DIRECT,6c33edb13117fd86 pubmatic.com,159302,DIRECT,5d62403b186f2ace decenterads.com,933,DIRECT onetag.com,694e68b73971b58,DIRECT sonobi.com,7ad1b9f952,RESELLER,d1a215d9eb5aee9e nativo.com,5677,DIRECT google.com,pub-1835489473992347,RESELLER,f08c47fec0942fa0 durationmedia.net,21968366300,DIRECT yahoo.com,57872,DIRECT smartadserver.com,3447,DIRECT xandr.com,11429,RESELLER,f5ab79cb980f11d1 xandr.com,12701,RESELLER,f5ab79cb980f11d1 rubiconproject.com,13702,DIRECT,0bfd66d529a55807 video.unrulymedia.com,3736557092,RESELLER rhythmone.com,3736557092,RESELLER,a670c89d4a324e47 admanmedia.com,812,DIRECT rhythmone.com,1059622079,RESELLER,a670c89d4a324e47 contextweb.com,560606,RESELLER,89ff185a4c4e857c amxrtb.com,105199579,DIRECT appnexus.com,12290,RESELLER,f5ab79cb980f11d1 indexexchange.com,191503,RESELLER,50b1c356f2c5c8fc pubmatic.com,158355,RESELLER,5d62403b186f2ace indexexchange.com,195491,RESELLER,50b1c356f2c5c8fc opera.com,pub5688296365760,DIRECT,55a0c5fd61378de3 indexexchange.com,192806,RESELLER,50b1c356f2c5c8fc Pubmatic.com,158565,RESELLER,5d62403b186f2ace smaato.com,1100042823,DIRECT,07bcf65f187117b4 rubiconproject.com,17608,RESELLER,0bfd66d529a55807 triplelift.com,10522,RESELLER,6c33edb13117fd86 smartadserver.com,4140,RESELLER appnexus.com,2081,RESELLER,f5ab79cb980f11d1 admixer.net,5e14a984-b5c9-4ffb-87e9-d8edba8492d3,DIRECT sovrn.com,268876,RESELLER,fafdf38b16bf6b2b lijit.com,268876,RESELLER,fafdf38b16bf6b2b openx.com,541031350,RESELLER,6a698e2ec38604c6 improvedigital.com,1556,RESELLER axonix.com,56222,RESELLER Contextweb.com,562309,RESELLER,89ff185a4c4e857c conversantmedia.com,100066,RESELLER,03113cd04947736d rubiconproject.com,12186,RESELLER,0bfd66d529a55807 onetag.com,72686cdf31f128b,RESELLER lemmatechnologies.com,552,RESELLER,7829010c5bebd1fb lemmatechnologies.com,144,RESELLER,7829010c5bebd1fb altitude-arena.com,FIRD0F0P6T2MLDMG7GCJFTBAI8,RESELLER leanback.digital,ESS-D666,RESELLER,b1d30350acaf0176 pubmatic.com,156494,RESELLER,5d62403b186f2ace smartadserver.com,3564,RESELLER admatic.com.tr,adm-pub-185375301865,RESELLER improvedigital.com,912,RESELLER pubmatic.com,159078,RESELLER,5d62403b186f2ace adform.com,2600,RESELLER stroeer.com,17938,RESELLER sovrn.com,380632,RESELLER,fafdf38b16bf6b2b lijit.com,380632,RESELLER,fafdf38b16bf6b2b lijit.com,380632-eb,DIRECT,fafdf38b16bf6b2b uis.mobfox.com,1424,RESELLER,5529a3d1f59865be openx.com,539249210,RESELLER,6a698e2ec38604c6 impactify.io,1146,DIRECT improvedigital.com,1058,RESELLER google.com,pub-1343218370015870,RESELLER,f08c47fec0942fa0 google.com,pub-4301669675472368,RESELLER,f08c47fec0942fa0 spotxchange.com,176703,RESELLER,7842df1d2fe2db34 spotx.tv,176703,RESELLER,7842df1d2fe2db34 appnexus.com,11197,RESELLER,f5ab79cb980f11d1 freewheel.tv,282594,RESELLER freewheel.tv,282786,RESELLER freewheel.tv,282802,RESELLER freewheel.tv,282818,RESELLER freewheel.tv,282850,RESELLER yahoo.com,1761548,RESELLER rubiconproject.com,19688,RESELLER,0bfd66d529a55807 advertising.com,9516,RESELLER smartadserver.com,2974,RESELLER google.com,pub-7019376976432612,RESELLER google.com,pub-5373693997956134,RESELLER,f08c47fec0942fa0 google.com,pub-4177862836555934,RESELLER,f08c47fec0942fa0 google.com,pub-1071602463683652,RESELLER,f08c47fec0942fa0 connectad.io,147,DIRECT pubmatic.com,55990,RESELLER,5d62403b186f2ace indexexchange.com,190906,DIRECT,50b1c356f2c5c8fc appnexus.com,8738,RESELLER,f5ab79cb980f11d1 EMXDGT.com,1138,DIRECT,1e1d41537f7cad7f sovrn.com,244287,DIRECT,fafdf38b16bf6b2b lijit.com,244287,DIRECT,fafdf38b16bf6b2b lijit.com,244287-eb,DIRECT,fafdf38b16bf6b2b yahoo.com,55248,DIRECT rubiconproject.com,17250,RESELLER,0bfd66d529a55807 xad.com,240,RESELLER,81cbf0a75a5e0e9a onetag.com,5d4e109247a89f6,DIRECT RTBHOUSE.COM,ofNe4Md3yOLt0qckkfER,DIRECT adpone.com,59e252f6de67f6c8d1f8,DIRECT connectad.io,50,DIRECT,85ac85a30c93b3e5 indexexchange.com,196713,DIRECT criteo.com,B-060278,DIRECT,9fac4a4a87c2a44f richaudience.com,06ehcbcfzk,DIRECT betweendigital.com,42666,DIRECT adform.com,2474,DIRECT,9f5210a2f0999e32 lijit.com,257429,RESELLER,fafdf38b16bf6b2b sovrn.com,257429,RESELLER,fafdf38b16bf6b2b openx.com,540603695,RESELLER,6a698e2ec38604c6 openx.com,539966405,DIRECT,6a698e2ec38604c6 pubmatic.com,157841,RESELLER,5d62403b186f2ace pubmatic.com,156383,RESELLER,5d62403b186f2ace smartadserver.com,1743,RESELLER,060d053dcf45cbf3 indexexchange.com,192450,DIRECT,50b1c356f2c5c8fc appnexus.com,10264,RESELLER,f5ab79cb980f11d1 appnexus.com,10264,DIRECT,f5ab79cb980f11d1 rubiconproject.com,20266,RESELLER,0bfd66d529a55807 rubiconproject.com,17210,RESELLER,0bfd66d529a55807 google.com,pub-2128757167812663,RESELLER,f08c47fec0942fa0 adtelligent.com,315476,DIRECT 33across.com,0010b00002T3JniAAF,RESELLER,bbea06d9c4d2853c bidtellect.com,1407,RESELLER,1c34aa2d85d45e93 contextweb.com,558355,RESELLER EMXDGT.com,1284,RESELLER,1e1d41537f7cad7f gumgum.com,13579,RESELLER,ffdef49475d318a9 improvedigital.com,1628,RESELLER lijit.com,310770,RESELLER,fafdf38b16bf6b2b onetag.com,59a18369e249bfb,RESELLER openx.com,541177116,RESELLER,6a698e2ec38604c6 pubmatic.com,157897,RESELLER,5d62403b186f2ace rhythmone.com,78519861,RESELLER,a670c89d4a324e47 sovrn.com,310770,RESELLER,fafdf38b16bf6b2b synacor.com,82151,RESELLER,e108f11b2cdf7d5b adform.com,2600,DIRECT admatic.com.tr,adm-pub-185375301865,DIRECT adyoulike.com,438e40b69c9e19f81b51401dce6e8be4,DIRECT,4ad745ead2958bf7 appnexus.com,11924,RESELLER,f5ab79cb980f11d1 appnexus.com,9733,RESELLER,f5ab79cb980f11d1 contextweb.com,558355,RESELLER,89ff185a4c4e857c e-planning.net,835fbafe26d231b1,DIRECT,c1ba615865ed87b2 gumgum.com,13579,DIRECT,ffdef49475d318a9 indexexchange.com,189529,DIRECT,50b1c356f2c5c8fc indexexchange.com,191973,RESELLER,50b1c356f2c5c8fc lijit.com,310770,DIRECT,fafdf38b16bf6b2b loopme.com,11378,RESELLER,6c8d5f95897a5a3b onetag.com,59a18369e249bfb,DIRECT pubmatic.com,156631,RESELLER,5d62403b186f2ace pubmatic.com,156813,DIRECT,5d62403b186f2ace pubmatic.com,159078,DIRECT,5d62403b186f2ace rhythmone.com,1767353092,RESELLER,a670c89d4a324e47 rubiconproject.com,12398,RESELLER,0bfd66d529a55807 rubiconproject.com,17184,DIRECT,0bfd66d529a55807 rubiconproject.com,21642,RESELLER,0bfd66d529a55807 sovrn.com,310770,DIRECT,fafdf38b16bf6b2b spotim.market,4446666,DIRECT,077e5f709d15bdbb stroeer.com,17938,DIRECT 152media.info,152M10,RESELLER rhythmone.com,3139274702404301777,DIRECT,a670c89d4a324e47 video.unrulymedia.com,3139274702404301777,DIRECT indexexchange.com,182257,RESELLER,50b1c356f2c5c8fc appnexus.com,6849,RESELLER,f5ab79cb980f11d1 rubiconproject.com,15268,RESELLER,0bfd66d529a55807 pubmatic.com,159277,RESELLER,5d62403b186f2ace advertising.com,28605,RESELLER openx.com,543878511,RESELLER,6a698e2ec38604c6 improvedigital.com,1699,RESELLER pubmatic.com,161562,RESELLER,5d62403b186f2ace vidoomy.com,2252369,DIRECT Qwarry.com,12,DIRECT,bf16059e4b3fb977 themediagrid.com,IH9PA4,DIRECT,35d5010d7789b49d criteo.com,B-059164,DIRECT,9fac4a4a87c2a44f themediagrid.com,7WYFHG,DIRECT,35d5010d7789b49d amxrtb.com,105199542,DIRECT appnexus.com,11786,RESELLER,f5ab79cb980f11d1 lijit.com,260380,RESELLER,fafdf38b16bf6b2b sovrn.com,260380,RESELLER,fafdf38b16bf6b2b appnexus.com,9393,RESELLER,f5ab79cb980f11d1 advertising.com,28305,RESELLER adform.com,2865,RESELLER smartadserver.com,3056,DIRECT viralize.com,4720,DIRECT adform.com,2688,RESELLER,9f5210a2f0999e32 adform.com,2437,RESELLER,9f5210a2f0999e32 freewheel.tv,1003361,DIRECT freewheel.tv,1003377,RESELLER freewheel.tv,939745,DIRECT freewheel.tv,941377,RESELLER pubmatic.com,156695,DIRECT,5d62403b186f2ace pubmatic.com,160405,RESELLER,5d62403b186f2ace improvedigital.com,1227,RESELLER spotxchange.com,241914,RESELLER,7842df1d2fe2db34 spotx.tv,241914,RESELLER,7842df1d2fe2db34 conversantmedia.com,100098,RESELLER,03113cd04947736d appnexus.com,4052,RESELLER contextweb.com,561998,RESELLER,89ff185a4c4e857c openx.com,540031703,RESELLER,6a698e2ec38604c6 pubmatic.com,158100,RESELLER,5d62403b186f2ace yahoo.com,55771,RESELLER,e1a5b5b6e3255540 loopme.com,11230,RESELLER,6c8d5f95897a5a3b freewheel.tv,1137761,RESELLER freewheel.tv,1138529,RESELLER freewheel.tv,962145,RESELLER freewheel.tv,962209,RESELLER improvedigital.com,1175,RESELLER freewheel.tv,1174465,RESELLER freewheel.tv,1174481,RESELLER undertone.com,3393,RESELLER appnexus.com,2234,RESELLER openx.com,537153564,RESELLER,6a698e2ec38604c6 ogury.com,f00b15ea-6210-4e34-bb76-384d7003d8e8,DIRECT appnexus.com,11470,RESELLER avantisvideo.com,8798,DIRECT Advertising.com,23598,DIRECT advertising.com,28918,DIRECT Appnexus.com,10062,DIRECT,f5ab79cb980f11d1 EMXDGT.com,1745,DIRECT,1e1d41537f7cad7f google.com,pub-2024690810381654,RESELLER,f08c47fec0942fa0 indexexchange.com,192106,DIRECT indexexchange.com,193375,RESELLER Pubmatic.com,159970,RESELLER,5d62403b186f2ace Pubmatic.com,160454,RESELLER,5d62403b186f2ace Pubmatic.com,160265,RESELLER,5d62403b186f2ace Contextweb.com,562357,DIRECT,89ff185a4c4e857c spotxchange.com,165877,RESELLER,7842df1d2fe2db34 spotx.tv,165877,RESELLER,7842df1d2fe2db34 rhythmone.com,871930104,DIRECT,a670c89d4a324e47 video.unrulymedia.com,871930104,DIRECT google.com,pub-5717092533913515,RESELLER,f08c47fec0942fa0 indexexchange.com,185192,DIRECT rhythmone.com,1149317856,DIRECT,a670c89d4a324e47 rubiconproject.com,17346,DIRECT,0bfd66d529a55807 pubmatic.com,157904,DIRECT,5d62403b186f2ace sharethrough.com,8a03a67b,DIRECT,d53b998a7bd4ecd2 indexexchange.com,186046,RESELLER,50b1c356f2c5c8fc spotxchange.com,212457,RESELLER spotx.tv,212457,RESELLER,7842df1d2fe2db34 pubmatic.com,156557,RESELLER pubmatic.com,158723,RESELLER,5d62403b186f2ace rubiconproject.com,18694,RESELLER,0bfd66d529a55807 openx.com,540274407,RESELLER,6a698e2ec38604c6 33across.com,0013300001kQj2HAAS,RESELLER,bbea06d9c4d2853c smaato.com,1100047713,RESELLER,07bcf65f187117b4 appnexus.com,9027,DIRECT aax.media,AAX23QE99,DIRECT Media.net,8CUOMF1PP,DIRECT pubmatic.com,158984,RESELLER,5d62403b186f2ace openx.com,543731411,RESELLER,6a698e2ec38604c6 indexexchange.com,192393,RESELLER districtm.io,100600,RESELLER sonobi.com,83729e979b,RESELLER onetag.com,66d66dec41ef0cc,RESELLER appnexus.com,10273,RESELLER,f5ab79cb980f11d1 indexexchange.com,192922,RESELLER,50b1c356f2c5c8fc onetag.com,5adb88524e24e50,RESELLER engagebdr.com,10427,RESELLER google.com,pub-9945624415527048,DIRECT,f08c47fec0942fa0 Media.net,8PR6YK195,DIRECT EMXDGT.com,1759,RESELLER,1e1d41537f7cad7f google.com,pub-7310785613215102,DIRECT,f08c47fec0942fa0 google.com,pub-8600492219386651,DIRECT,f08c47fec0942fa0 e-planning.net,d6e04fe7533a7d3b,DIRECT,c1ba615865ed87b2 indexexchange.com,190243,DIRECT richaudience.com,25BiP9IMgN,DIRECT aol.com,57992,RESELLER,e1a5b5b6e3255540 Yahoo.com,57992,RESELLER,e1a5b5b6e3255540 sonobi.com,8efb591506,DIRECT,d1a215d9eb5aee9e sonobi.com,4d443a3ea2,RESELLER,d1a215d9eb5aee9e adriver.ru,187150,DIRECT smartadserver.com,2491,RESELLER advertising.com,21483,DIRECT,e1a5b5b6e3255540 improvedigital.com,1010,RESELLER indexexchange.com,193216,RESELLER admanmedia.com,722,DIRECT video.unrulymedia.com,3948367200,RESELLER rhythmone.com,3948367200,RESELLER,a670c89d4a324e47 appnexus.com,8804,RESELLER,f5ab79cb980f11d1 smartadserver.com,3713,RESELLER improvedigital.com,1668,RESELLER indexexchange.com,191497,RESELLER openx.com,540866936,RESELLER,6a698e2ec38604c6 appnexus.com,10040,RESELLER rubiconproject.com,19814,RESELLER,0bfd66d529a55807 spotxchange.com,178357,RESELLER,7842df1d2fe2db34 spotx.tv,178357,RESELLER,7842df1d2fe2db34 pubmatic.com,158810,RESELLER,5d62403b186f2ace pubmatic.com,158481,DIRECT,5d62403b186f2ace spotx.tv,238936,RESELLER,7842df1d2fe2db34 rubiconproject.com,19668,RESELLER,0bfd66d529a55807 indexexchange.com,190856,RESELLER,50b1c356f2c5c8fc pubmatic.com,158615,RESELLER,5d62403b186f2ace indexexchange.com,183965,RESELLER,50b1c356f2c5c8fc pubmatic.com,156458,RESELLER,5d62403b186f2ace pubmatic.com,156325,RESELLER,5d62403b186f2ace pubmatic.com,156674,RESELLER,5d62403b186f2ace rubiconproject.com,18222,RESELLER,0bfd66d529a55807 rubiconproject.com,16114,DIRECT azeriondigital.com,43710415,DIRECT appnexus.com,12223,RESELLER,f5ab79cb980f11d1 improvedigital.com,1210,RESELLER improvedigital.com,1221,RESELLER pubmatic.com,150561,RESELLER,5d62403b186f2ace EMXDGT.com,1836,DIRECT,1e1d41537f7cad7f EMXDGT.com,1289,DIRECT,1e1d41537f7cad7f advertising.com,28335,DIRECT,e1a5b5b6e3255540 smilewanted.com,1362,DIRECT adyoulike.com,b3e21aeb2e950aa59e5e8cc1b6dd6f8e,DIRECT,4ad745ead2958bf7 loopme.com,11013,DIRECT,6c8d5f95897a5a3b connectad.io,204,DIRECT,85ac85a30c93b3e5 EMXDGT.com,1701,DIRECT,1e1d41537f7cad7f quantum-advertising.com,6222,RESELLER themediagrid.com,BG415O,DIRECT,35d5010d7789b49d smartadserver.com,3392,DIRECT appnexus.com,10212,RESELLER improvedigital.com,1633,RESELLER yahoo.com,58977,RESELLER,e1a5b5b6e3255540 onetag.com,75779831fd8c740,DIRECT adyoulike.com,22e5955a10a7f98b037f13dd297cdd74,DIRECT,4ad745ead2958bf7 freewheel.tv,1089937,DIRECT freewheel.tv,1099761,RESELLER bliink.io,cfe6f06e-2ff0-11eb-8d68-7aaa96b266b5,DIRECT gothamads.com,1750,DIRECT,d9c86e5dec870222 connectad.io,190,DIRECT,85ac85a30c93b3e5 improvedigital.com,1937,RESELLER e-planning.net,54275499d4eb431b,DIRECT,c1ba615865ed87b2 trmqb.com,4512,DIRECT ssp.logan.ai,LG9,RESELLER opera.com,pub6060502141568,DIRECT,55a0c5fd61378de3 openx.com,544015448,RESELLER,6a698e2ec38604c6 synacor.com,82460,DIRECT,e108f11b2cdf7d5b video.unrulymedia.com,123476257,RESELLER bizzclick.com,30,RESELLER,7e936b1feafdaa61 betweendigital.com,43818,RESELLER smaato.com,1100042823,RESELLER,07bcf65f187117b4 mobilefuse.com,3719,RESELLER,71e88b065d69c021 conversantmedia.com,100269,RESELLER,03113cd04947736d outbrain.com,002d7f7ba0bd74452f2b155d0dfb5cd6c8,RESELLER yahoo.com,58935,RESELLER,e1a5b5b6e3255540 inmobi.com,f58140d7af1a4fcb83deb5b1c76f0c04,RESELLER,83e75a7ae333ca9d tpmn.io,472,RESELLER seedtag.com,619f620afe426c0700a5c30d,DIRECT seedtag.com,61a78375e0fb8f0800ec50fb,DIRECT seedtag.com,61a783c8517244070096f118,DIRECT seedtag.com,61a783f0e0fb8f0800ec50fc,DIRECT seedtag.com,61a7804cfe829e0700f0db81,DIRECT seedtag.com,61a7849ac342880700fc6da2,DIRECT seedtag.com,61a784f8fe829e0700f0dbba,DIRECT seedtag.com,61a78466517244070096f119,DIRECT seedtag.com,61a78446c342880700fc6da1,DIRECT pubmatic.com,157743,DIRECT,5d62403b186f2ace spotxchange.com,249286,DIRECT,7842df1d2fe2db34 spotx.tv,249286,DIRECT,7842df1d2fe2db34 rubiconproject.com,17280,DIRECT,0bfd66d529a55807 33across.com,0010b00002MptHCAAZ,DIRECT,bbea06d9c4d2853c indexexchange.com,191730,RESELLER improvedigital.com,1680,RESELLER smartadserver.com,3050,DIRECT contextweb.com,560288,DIRECT,89ff185a4c4e857c openx.com,537149888,DIRECT,6a698e2ec38604c6 districtm.io,101760,DIRECT,3fd707be9c4527c3 xandr.com,4009,DIRECT richaudience.com,ns9qrKJLKD,DIRECT aerserv.com,2750,DIRECT,2ce496b9f80eb9fa aolcloud.net,4687,DIRECT mobfox.com,74240,DIRECT openx.com,539625136,DIRECT smaato.com,1100037086,DIRECT adyoulike.com,83d15ef72d387a1e60e5a1399a2b0c03,DIRECT yahoo.com,58578,DIRECT,e1a5b5b6e3255540 aol.com,58578,DIRECT,e1a5b5b6e3255540 advertising.com,29034,DIRECT adform.com,1889,RESELLER,9f5210a2f0999e32 condigolabs.com,c6blkn6kv5dumh3tsfj0,RESELLER 33across.com,0015a00002vNEdMAAW,DIRECT,bbea06d9c4d2853c conversantmedia.com,100141,DIRECT gumgum.com,15500,RESELLER,ffdef49475d318a9 justpremium.com,2976,RESELLER appnexus.com,2758,RESELLER,f5ab79cb980f11d1 rubiconproject.com,23434,RESELLER,0bfd66d529a55807 openx.com,537149485,RESELLER,6a698e2ec38604c6 admanmedia.com,799,RESELLER smartadserver.com,4005,RESELLER 33across.com,0013300001r0t9mAAA,RESELLER,bbea06d9c4d2853c vidoomy.com,62496,DIRECT google.com,pub-2831120411392012,RESELLER,f08c47fec0942fa0 tremorhub.com,4cywq-a04wk,RESELLER,1a4e959a1b50034a yieldmo.com,2731991718797714293,DIRECT adform.com,2742,RESELLER advertising.com,22762,RESELLER aol.com,22762,RESELLER adtech.com,11303,RESELLER advertising.com,26631,RESELLER appnexus.com,12475,RESELLER,f5ab79cb980f11d1 pubmatic.com,156498,RESELLER,5d62403b186f2ace freewheel.tv,872257,RESELLER freewheel.tv,894193,RESELLER openx.com,540804929,RESELLER,6a698e2ec38604c6 lkqd.net,430,RESELLER,59c49fa9598a0117 lkqd.com,430,RESELLER,59c49fa9598a0117 districtm.io,101540,RESELLER,3fd707be9c4527c3 spotxchange.com,218443,RESELLER,7842df1d2fe2db34 spotx.tv,218443,RESELLER,7842df1d2fe2db34 emxdgt.com,1495,RESELLER,1e1d41537f7cad7f beachfront.com,6547,RESELLER smartadserver.com,3136,RESELLER smartadserver.com,1963,RESELLER smartadserver.com,3276,RESELLER improvedigital.com,1738,RESELLER conversantmedia.com,100112,DIRECT,03113cd04947736d appnexus.com,4052,RESELLER,f5ab79cb980f11d1 aol.com,55011,RESELLER,e1a5b5b6e3255540 indexexchange.com,192311,RESELLER indexexchange.com,193069,RESELLER loopme.com,11058,RESELLER,6c8d5f95897a5a3b google.com,pub-7995104076770938,DIRECT,f08c47fec0942fa0 appnexus.com,8790,RESELLER,f5ab79cb980f11d1 indexexchange.com,187924,DIRECT indexexchange.com,189458,DIRECT openx.com,540322758,RESELLER,6a698e2ec38604c6 pubmatic.com,157102,RESELLER,5d62403b186f2ace pubmatic.com,157163,RESELLER,5d62403b186f2ace pubmatic.com,157752,RESELLER,5d62403b186f2ace rubiconproject.com,13894,RESELLER,0bfd66d529a55807 rubiconproject.com,18008,RESELLER,0bfd66d529a55807 yahoo.com,56860,RESELLER,e1a5b5b6e3255540 aol.com,56860,RESELLER,e1a5b5b6e3255540 rhythmone.com,274200170,RESELLER,a670c89d4a324e47 video.unrulymedia.com,274200170,RESELLER,a670c89d4a324e47 yahoo.com,59652,RESELLER,e1a5b5b6e3255540 appnexus.com,1868,RESELLER appnexus.com,11664,RESELLER EMXDGT.com,273,RESELLER,1e1d41537f7cad7f indexexchange.com,184110,RESELLER,50b1c356f2c5c8fc indexexchange.com,184349,RESELLER,50b1c356f2c5c8fc indexexchange.com,195924,DIRECT indexexchange.com,183875,RESELLER,50b1c356f2c5c8fc indexexchange.com,184626,RESELLER,50b1c356f2c5c8fc openx.com,544096208,RESELLER,6a698e2ec38604c6 pubmatic.com,156971,RESELLER,5d62403b186f2ace pubmatic.com,133799,RESELLER,5d62403b186f2ace pubmatic.com,156078,RESELLER,5d62403b186f2ace pubmatic.com,157840,RESELLER,5d62403b186f2ace pubmatic.com,155967,RESELLER,5d62403b186f2ace pubmatic.com,160048,RESELLER,5d62403b186f2ace pubmatic.com,156084,RESELLER,5d62403b186f2ace contextweb.com,562258,RESELLER,89ff185a4c4e857c telaria.com,4jdlm-4qsx6,RESELLER,1a4e959a1b50034a tremorhub.com,4jdlm-4qsx6,RESELLER,1a4e959a1b50034a triplelift.com,9979,RESELLER,6c33edb13117fd86 media.net,8CUIHQJ4B,RESELLER indexexchange.com,196845,RESELLER,50b1c356f2c5c8fc sovrn.com,378732,RESELLER,fafdf38b16bf6b2b lijit.com,378732,RESELLER,fafdf38b16bf6b2b 33across.com,0010b00002EdWnZAAV,RESELLER,bbea06d9c4d2853c pubmatic.com,161784,RESELLER,5d62403b186f2ace pubmatic.com,161593,RESELLER,5d62403b186f2ace improvedigital.com,1790,RESELLER smartadserver.com,3554,RESELLER 33across.com,0015a00002oUk4aAAC,RESELLER,bbea06d9c4d2853c richaudience.com,1BTOoaD22a,RESELLER pubmatic.com,81564,RESELLER,5d62403b186f2ace rubiconproject.com,13510,RESELLER yahoo.com,49648,RESELLER rubiconproject.com,24298,RESELLER,0bfd66d529a55807 inmobi.com,8f261ace12c3486ba2e0d2011cd97976,DIRECT,83e75a7ae333ca9d adform.com,2736,RESELLER,9f5210a2f0999e32 pubmatic.com,160987,RESELLER,5d62403b186f2ace pubmatic.com,160998,RESELLER,5d62403b186f2ace google.com,pub-7019376976432612,RESELLER,f08c47fec0942fa0 yahoo.com,59133,RESELLER,e1a5b5b6e3255540 yahoo.com,59356,RESELLER,e1a5b5b6e3255540 EMXDGT.com,1966,RESELLER,1e1d41537f7cad7f smartadserver.com,3056,RESELLER pubmatic.com,161527,RESELLER,5d62403b186f2ace rubiconproject.com,23844,DIRECT,0bfd66d529a55807 yahoo.com,59531,RESELLER,e1a5b5b6e3255540 smartadserver.com,4071,RESELLER 152media.info,152M1,RESELLER indexexchange.com,189372,RESELLER,50b1c356f2c5c8fc consumable.com,2001326,RESELLER,aefcd3d2f45b5070 Media.net,8PR6YK195,RESELLER rubiconproject.com,23280,RESELLER,0bfd66d529a55807 smartadserver.com,4102,RESELLER vidoomy.com,57205,RESELLER EMXDGT.com,2007,DIRECT,1e1d41537f7cad7f uis.mobfox.com,1263,RESELLER,5529a3d1f59865be loopme.com,11470,RESELLER,6c8d5f95897a5a3b onetag.com,5927d926323dc2c,DIRECT yandex.com,97790217,DIRECT openx.com,557083110,RESELLER,6a698e2ec38604c6 yahoo.com,59702,DIRECT,e1a5b5b6e3255540 loopme.com,11468,RESELLER,6c8d5f95897a5a3b contextweb.com,562499,RESELLER,89ff185a4c4e857c indexexchange.com,194730,RESELLER outbrain.com,00fe7cdd9f63b40ea93c0c4ae346bf4541,DIRECT vi.ai,987349031605160,DIRECT xandr.com,10736,RESELLER freewheel.tv,1220655,RESELLER indexexchange.com,193091,RESELLER,50b1c356f2c5c8fc improvedigital.com,1863,RESELLER loopme.com,11314,RESELLER,6c8d5f95897a5a3b triplelift.com,11656,RESELLER,6c33edb13117fd86 appnexus.com,13227,RESELLER yandex.com,95746987,RESELLER rubiconproject.com,24386,RESELLER,0bfd66d529a55807 ### THE MONEYTIZER END ### ### Sovrn ### sovrn.com, 306258, DIRECT, fafdf38b16bf6b2b lijit.com, 306258, DIRECT, fafdf38b16bf6b2b lijit.com, 306258-eb, DIRECT, fafdf38b16bf6b2b ### Sovrn END ### ### Revcontent ### revcontent.com, 92656, DIRECT engagebdr.com, 10304, RESELLER synacor.com, 82291, RESELLER, e108f11b2cdf7d5b indexexchange.com, 192143, RESELLER, 50b1c356f2c5c8fc ### Revcontent END ### ### 33Across ### 33across.com, 0010b00002cnuc6AAA, DIRECT, bbea06d9c4d2853c rubiconproject.com, 21642, RESELLER, 0bfd66d529a55807 rubiconproject.com, 21434, RESELLER, 0bfd66d529a55807 rubiconproject.com, 21720, RESELLER, 0bfd66d529a55807 pubmatic.com, 158569, RESELLER, 5d62403b186f2ace openx.com, 540995201, RESELLER, 6a698e2ec38604c6 aol.com, 47594, RESELLER, e1a5b5b6e3255540 yahoo.com, google.com, pub-8787923930478618, RESELLER, f08c47fec0942fa0 yahoo.com,
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